Endocrine Abstracts

Background and aims: People with type 1 diabetes (T1D) are increasingly suffering from overweight and at risk of developing insulin resistance (IR). IR may hamper glucose control and augment the risk of cardiovascular disease (CVD). Simultaneously, non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent in T1DM. The pathophysiology of NAFLD is linked to IR. The gold standard to assess IR is the euglycaemic clamp, an invasive and time-consuming test that ca...

Background and aims: Low levels of testosterone and non-alcoholic fatty liver disease (NAFLD) in obese men are both linked to the metabolic syndrome, but the independent association between testosterone and NAFLD needs to be elucidated. In this cross-sectional analysis the association between total testosterone (total T) and calculated free testosterone (cFT) on the one hand and NAFLD, non-alcoholic steatohepatitis (NASH) and fibrosis on the other hand was investigated in obes...

Background and Aims: Incorrect injection technique can cause lipohypertrophy resulting in unpredictable insulin release. We aimed to assess the impact of a correct injection technique and lipohypertrophy on HbA1c, hypoglycemia and glucose variability.Methods: 171 insulin-injecting people with diabetes were prospectively evaluated for 6 months. 146 subjects completed the study (75 type 1, 71 type 2). They were provided extensive education concerning injec...

Background and aims: So far, HbA1c is the only metric of glucose control showing a strong association with chronic complications. However, it does not reflect short-term glycemic variability nor provides guidance in decreasing risk of hypoglycemia. More widespread use of continuous glucose monitoring (CGM) has changed the way people with type 1 diabetes (T1D) manage their glycemia by providing information about glycemic variability and time spent in different glucose ranges.</...